Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing
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چکیده
منابع مشابه
Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing.
Macrophages contribute to the development of atherosclerosis through pinocytotic deposition of native LDL-derived cholesterol in macrophages in the vascular wall. Inhibiting macrophage-mediated lipid deposition may have protective effects in atheroprone vasculature, and identifying mechanisms that potentiate this process may inform potential therapeutic interventions for atherosclerosis. Here, ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2016
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci85880